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Salud pública Méx ; 53(1): 40-47, Jan.-Feb. 2011. graf, tab
Article in English | LILACS | ID: lil-574963

ABSTRACT

OBJECTIVE: We present a model for the 2009 influenza epidemic in Mexico to describe the observed pattern of the epidemic from March through the end of August (before the onset of the expected winter epidemic) in terms of the reproduction number and social isolation measures. MATERIAL AND METHODS: The model uses a system of ordinary differential equations. Computer simulations are performed to optimize trajectories as a function of parameters. RESULTS: We report on the theoretical consequences of social isolation using published estimates of the basic reproduction number. The comparison with actual data provides a reasonable good fit. CONCLUSIONS: The pattern of the epidemic outbreak in Mexico is characterized by two peaks resulting from the application of very drastic social isolation measures and other prophylactic measures that lasted for about two weeks. Our model is capable of reproducing the observed pattern.


OBJETIVO: Se presenta un modelo de la epidemia de influenza en México en 2009 para describir el patrón observado desde marzo hasta finales de agosto (antes del inicio de la epidemia invernal), en términos del número reproductivo y las medidas de aislamiento social. MATERIAL Y MÉTODOS: El modelo es un sistema de ecuaciones diferenciales ordinarias. Se realizaron simulaciones computacionales para la optimización de trayectorias como función de los parámetros. RESULTADOS: Se exploran las consecuencias de esta última medida combinada con los valores estimados en la literatura médica del número reproductivo básico. CONCLUSIONES: El patrón de la epidemia mexicana de influenza es bimodal debido a la aplicación del aislamiento social y otras medidas profilácticas que duró aproximadamente dos semanas. Este modelo es capaz de reproducir el patrón observado.


Subject(s)
Humans , Computer Simulation , Influenza A Virus, H1N1 Subtype , Influenza, Human/epidemiology , Models, Theoretical , Patient Isolation , Quarantine , Disease Outbreaks/prevention & control , Disease Outbreaks/statistics & numerical data , Disease Susceptibility , Immunity, Innate , Influenza, Human/prevention & control , Influenza, Human/virology , Mexico/epidemiology , Patient Isolation/legislation & jurisprudence , Quarantine/legislation & jurisprudence , Seasons , Time Factors , Travel
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